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Proteins act alone or in complexes to perform many cellular functions.F('G   fp=___PPT10i.+iY"+D=' = @B +"( /'p((  (~ (  x0e0e?Rectangle 2`P   , Inside Proteins (ˆ}v)8 <*   Q (  x`~L 0e0e?Rectangle 3m   The twenty amino acids commonly found in proteins: A Ala Alanine C Cys Cysteine D Asp Aspartic Acid E Glu Glutamic Acid Z     fp=___PPT10i.lgee+D=' = @B +" ,(  ,H ,  xL 0e0e?Rectangle 2`   |Continued & 4  E    ,  x sB 0e0e?Rectangle 3W  AF Phe Phenylalanine G Gly Glycine H His Histidine I Ile Isoleucine K Lys Lysine L Leu Leucine M Met Methionine N Asn Asparagine P Pro Proline^ Z         fp=___PPT10i.mgSe+D=' = @B +"> E=0%(  0H 0  xS5 0e0e?Rectangle 2`j   |Continued & 4  E   0  xsE 0e0e?Rectangle 3Wb  Q Gln Glutamine R Arg Arginine S Ser Sreine T Thr Threonine V Val Valine W Trp Trptophan Y Tyr Tyrosine          fp=___PPT10i.ng{5<+D=' = @B +" 4(  4$ 4  j`tE 0e0e? jL 1   fAbout Proteins   4  z@E 0e0e?gQ[HrbMn@S 2   Proteins are large biomolecules, or macromolecules, consisting of one or more long chains (sequences) of amino acid residues. 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(*) Proteins differ from one another primarily in their sequence of amino acids of their genes results in protein folding into a specific 3-dim. Structure that determines its activity.Zlpg>%   fp=___PPT10i.?+D=' = @B +"o vn<V(  <0 <  xL 0e0e?Rectangle 2`   dHuman Genome Project E  <  A??genemanPicture 3genemanl  fp=___PPT10i._uU+D=' = @B +"% }@e(  @ @  j xE 0e0e? jL 1gW   ]Goals    @  z@Q 0e0e?gQ[HrbMn@S 2   <Identify all the approximate 30,000 genes in human DNA. Determine the sequences of all 3 billion chemical base pairs that make up the human DNA. Store this sequence (databases). Improve tools for data analysis.*8YB   fp=80___PPT10.C" 6.D(  D( D  j`~E 0e0e? jL 1   jImportant Issues(   D  z`Y5 0e0e?gQ[HrbMn@S 2   zDevelop new technologies in sequencing the DNA sequences. Transfer related technologies to the  private sector, and address the ethical, legal, and issues (social) that may arise from HGP.&   fp=80___PPT10.ٶ" H(  H" H  jE 0e0e? jL 1   d Milestones (    H  zuE 0e0e?gQ[HrbMn@S 2   KIn 1990, the project was initiated jointly by U. S. Department of Energy and the National Institute of Health. A working draft was completed of the entire human genome in 2000 and the analyses are published one year later. 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Reciprocal translocation: A segment of a chromosome that contains a telomere is exchanged with a segment of another chromosome that also contains a telomere. Telomere: z|/fw8huirgrԚ+gzvDNA͑^R \O(u/fOcgrԚv[te'`Tc6R0}ހRˆ1g0 1ueDNAv_j6R k!kgrԚ_ ^r NvgrԚ+gz_!ql0Vdk w8huir(WgrԚ+gzoSQz|N\OpS͑zhvR0D-HcggMg g ggggg             fp=80___PPT10.pgq"> h~(  hv h  jE 0e0e? jL 1gWj  F>___PPT9  jMore&   h  zx 0e0e?gQ[HrbMn@S 2 j F>___PPT9  6. Fusion: Two chromosomes are joined into one. 7. Fission: One chromosome splits into two (inverse of fusion). 8. Horizontal transfer: A segment of the genome is copied from one genome to another. (This is common mainly in unicelluar organisms.)f ) 6A-   fp=80___PPT10.p" |tl\(  ly l  j 0e0e? jL 1gWj  F>___PPT9  mNotices&   l  z xB 0e0e?gQ[HrbMn@S 2 j F>___PPT9  All the operations act on a segment at the level of DNA segments rather on nucleotides. 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DnD ǦCﱴs ChallengesTypes of rearrangements Continued KMoreMoreNoticesHomologous (P)  ϥΦr GDD vD_USERUSER  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root EntrydO)PicturesapCurrent UserSummaryInformation(EPowerPoint Document(DocumentSummaryInformation8